University of North Carolina at Chapel Hill's Gene Therapy Department

Gene Therapy Department - University of North Carolina at Chapel Hill

Samulski Lab
Kafri Lab
Monahan Lab
McCown Lab

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Tal Kafri MD, PhD

Associate Professor

MD/PhD Hebrew University, Jerusalem

919.843.7635

kafri@med.unc.edu

Research Interests: The development of lentivirus vectors for gene therapy, and on basic science of

HIV-1 biology.

Publications:

Bayer M, Kantor B, Cockrell A, Ma H, Zeithaml B, Li X, McCown T, Kafri T. A Large U3 Deletion Causes Increased In Vivo Expression From a Nonintegrating Lentiviral Vector. Mol Ther. 2008 Sep 16. [Epub ahead of print]

Cockrell AS, Kafri T. Gene delivery by lentivirus vectors. Mol Biotechnol. 2007 Jul; 36 ( 3 ): 184-204 . Review.

Li C, Hirsch M, Asokan A, Zeithaml B, Ma H, Kafri T, Samulski RJ. Adeno-associated virus type 2 (AAV2) capsid-specific cytotoxic T lymphocytes eliminate only vector-transduced cells coexpressing the AAV2 capsid in vivo. J Virol. 2007 Jul; 81 ( 14 ): 7540-7 . Epub 2007 May 2.

Bahi A, Boyer F, Kafri T, Dreyer JL. Silencing urokinase in the ventral tegmental area in vivo induces changes in cocaine-induced hyperlocomotion. J Neurochem. 2006 Sep; 98 ( 5 ): 1619-31 .

Cockrell AS, Ma H, Fu K, McCown TJ, Kafri T. A trans-lentiviral packaging cell line for high-titer conditional self-inactivating HIV-1 vectors. Mol Ther. 2006 Aug; 14 ( 2 ): 276-84 . Epub 2006 Mar 3.

Bahi A, Boyer F, Gumy C, Kafri T, Dreyer JL. In vivo gene delivery of urokinase-type plasminogen activator with regulatable lentivirus induces behavioural changes in chronic cocaine administration. Eur J Neurosci. 2004 Dec; 20 ( 12 ): 3473-88 .

Haack K, Cockrell AS, Ma H, Israeli D, Ho SN, McCown TJ, Kafri T. Transactivator and structurally optimized inducible lentiviral vectors. Mol Ther. 2004 Sep; 10 ( 3 ): 585-96 .

Logan AC, Haas DL, Kafri T, Kohn DB. Integrated self-inactivating lentiviral vectors produce full-length genomic transcripts competent for encapsidation and integration. J Virol. 2004 Aug; 78 ( 16 ): 8421-36 .

Ma H, Kafri T. A single-LTR HIV-1 vector optimized for functional genomics applications. Mol Ther. 2004 Jul; 10 ( 1 ): 139-49 .

Bahi A, Boyer F, Kafri T, Dreyer JL. CD81-induced behavioural changes during chronic cocaine administration: in vivo gene delivery with regulatable lentivirus. Eur J Neurosci. 2004 Mar; 19 ( 6 ): 1621-33 .

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