Monahan Lab

Paul E. Monahan, MD

Associate Professor, Department of Pediatrics,
Division of Hematology/Oncology

Attending Physician, Comprehensive Hemophilia Diagnostic and Treatment Center; University of North Carolina at Chapel Hill, N.C.

MD, University of Virginia School of Medicine

Laboratory phone: 919.843.4984

monoman@med.unc.edu

Publications:

• Keravala A, Chavez CL, Hu G, Woodard LE, Monahan PE, Calos MP. Long-term phenotypic correction in factor IX knockout mice by using phiC31 integrase-mediated gene therapy. Gene Ther. 2011 Mar 17. PMID: 21412285

• Monahan PE, Lothrop CD, Sun J, Hirsch ML, Kafri T, Kantor B, Sarkar R, Tillson DM, Elia JR, Samulski RJ. Proteasome inhibitors enhance gene delivery by AAV virus vectors expressing large genomes in hemophilia mouse and dog models: a strategy for broad clinical application.  Mol Ther. 2010 Nov;18(11):1907-16. Epub 2010 Aug 10.

• Monahan PE. The expanding menagerie: animal models of hemophilia A. J Thromb Haemost. 2010 Nov;8(11):2469-71. doi: 10.1111/j.1538-7836.2010.04053.x. No abstract available. PMID: 21251193

• Monahan PE, Di Paola J. Recombinant factor IX for clinical and research use. Semin Thromb Hemost. 2010 Jul;36(5):498-509. Epub 2010 Jul 14.
  

• Monahan PE, Sun J.  Hemophilic synovitis: Factor VII and the potential role of extravascular factor VIIa. Thromb Res. 2010. Apr;125 Suppl 1:S63-6.
  
  

• Monahan PE, Liesner R, Sullivan ST, Ramirez ME, Kelly P, Roth DA.  Safety and efficacy of investigator-prescribed BeneFIX prophylaxis in children less than 6 years of age with severe haemophilia B.  Haemophilia. 2010 May; 16(3):460-8.

  
  
• Kantor B, Ma H, Webster-Cyriaque J, Monahan PE, Kafri T.  Epigenetic activation of unintegrated HIV-1 genomes by gut-associated short chain fatty acids and its implications for HIV infection.  Proc Natl Acad Sci USA. 2009 Nov 3;106(44):18786-91.
  
  
• Gui T, Reheman A, Ni H, Gross PL, Yin F, Monroe D, Monahan PE, Stafford DW.  Abnormal hemostasis in a knock-in mouse carrying a variant of factor IX with impaired binding to collagen type IV.  J Thromb Haemost.  2009 Nov;7(11):1843-51.
  
  
• Weston BW, Monahan PE.  Familial deficiency of vitamin K-dependent clotting factors.  Haemophilia. 2008 Nov;14(6):1209-13.
  
  
• Monahan PE.  Factor IX: Insights from knock-out and genetically engineered mice.  Thromb Haemost. 2008 Oct;100(4):563-75.
  
  

• Sun J, Hakobyan N, Valentino LA, Feldman BL, Samulski RJ, Monahan PE. Intra-articular factor IX protein or gene replacement protects against development of hemophilic synovitis in the absence of circulating factor IX. Blood . 2008 Aug 20. [Epub ahead of print]

• Monahan PE.Experimental animal use in the study of haemophilic bleeding.Haemophilia. 2008 Jan; 14 (1): 112-6. Epub 2007 Dec 10. No abstract available.

• Bhangoo S, Ren D, Miller RJ, Henry KJ, Lineswala J, Hamdouchi C, Li B, Monahan PE, Chan DM, Ripsch MS, White FA.Delayed functional expression of neuronal chemokine receptors following focal nerve demyelination in the rat: a mechanism for the development of chronic sensitization of peripheral nociceptors. Mol Pain . 2007 Dec 12; 3: 38.

• Wu Z, Sun J, Zhang T, Yin C, Yin F, Van Dyke T, Samulski RJ, Monahan PE.Optimization of self-complementary AAV vectors for liver-directed expressionresults in sustained correction of hemophilia B at low vector dose. Mol Ther. 2008 Feb; 16 (2): 280-9 . Epub 2007 Dec 4.

• Monahan PE. Neonatal immune tolerance for hemophilia: can we "tolerate" new paradigms for gene therapy trials?  J Thromb Haemost. 2007 Sep; 5 (9): 1801-4 . No abstract available.

• Gui T, Reheman A, Funkhouser WK, Bellinger DA, Hagaman JR, Stafford DW, Monahan PE, Ni H. In vivo response to vascular injury in the absence of factor IX: examination in factor IX knockout mice. Thromb Res. 2007; 121 (2): 225-34 . Epub 2007 May 9.

• Zhang TP, Jin DY, Wardrop RM 3rd, Gui T, Maile R, Frelinger JA, Stafford DW, Monahan PE. Transgene expression levels and kinetics determine risk of humoral immune response modeled in factor IX knockout and missense mutant mice. Gene Ther . 2007 Mar; 14 ( 5 ): 429-40 . Epub 2006 Oct 26.

• Stitzenberg KB, Piehl MD, Monahan PE, Phillips JD. Interval laparoscopic appendectomy for appendicitis complicated by pylephlebitis. JSLS . 2006 Jan-Mar; 10 ( 1 ): 108-13 . Review.