Jeff Beecham, PhD

Vector Laboratories Director

PhD, National Cancer Institute, NIH

919.962.1245

jbeecham@email.unc.edu

Publications:

• Ripley R, Mahesh N, Press W, Lee J-S, Aguilar-Cordova E, Beecham EJ. 2002. Production criteria in the development of a K562-based vaccine platform. Bioprocessing, 1(3):31-35.
  
  
• Yun CY, Nolan KF, Beecham EJ, Reisfeld RA, Junghans RP. 2000. Targeting of T lymphocytes to melanoma cells through chimeric anti-GD3 immunoglobulin T-cell receptors. Neoplasia, 2(5):449-459.
  
  
• Beecham EJ, Ma Q, Ripley R, Junghans RP. 2000. Coupling CD28 co-stimulation to primary signals transmitted through an anti-CEA IgTCR molecule; Dynamics of T cell proliferation and death. J. of Immunotherapy, 23(6):631-642.
  
  
• Beecham EJ, Ortize-Pujols S, Junghans RP. 2000. Dynamics of tumor cell killing by human T cells armed with an anti-CEA chimeric immunoglobulin T cell receptor. J. Immunotherapy, 23(3):332-343.
  
  
• Nolan KF, Yun CO, Akamatsu Y, Murphy JC, Leung S-O, Beecham EJ and Junghans, R.P. 2000. Bypassing immunization: Optimized design of "designer T cells" against carcionembryonic antigen (CEA)-expressing tumors, and lack of suppression by soluble CEA. Clin. Can. Res., 5:3928-3941.
  
  
• Young W-B, Beecham EJ, Lindberg GL, Link CJ. 1999. Restriction mapping of retroviral vector episomal DNA. Biotechniques, 28:562-565.
  
  
• Rudaina HA, Beecham EJ, Bohr VA, Gearhart PJ. 1999. Less repair of pyrimidine dimers and single-strand breaks in genes by scid cells. Biochem. Biophys. Res. Comm., 264:878-882.
  
  
• Beecham EJ, Owens J, Bohr VA, Mushinski JF. 1996. Evidence that excision repair and transcription can function independently in normal mouse lymphocytes. Carcinogenesis, 18:687-694.
  
  
• Beecham EJ, Umthun A, Link C. 1995. Human gene therapy trials for HIV-1. J Biotech. Healthcare, 2:91-102.
  
  
• Lariment F, Beecham EJ, Link CJ, Bohr VA. 1995. DNA repair in the endogenous and episomal amplified c-myc oncogene loci in human tumor cells. Oncogene, 10:1639-1645.
  
  
• Link CJ, Beecham EJ. 1994. Human gene therapy trials for cancer. J Biotech Healthcare, 2:183-195.
  
  
• Beecham EJ, Jones GM, Huppi K, Link CJ, Potter M, Mushinski JF, Bohr VA. 1994. DNA repair defects associated with translocation break site regions. Mol. Cell. Biol., 14:1204-12.
  
  
• LeDoux SP, Wilson GL, Beecham EJ, Stevnsner T, Wassermann K, Bohr VA. 1992. Repair of mitochondrial DNA after various types of DNA damage in Chinese hamster ovary cells. Carcinogenesis, 13:1967-1973.
  
  
• Beecham EJ, Mushinski JF, Shacter E, Potter M, Bohr VA. 1991. DNA repair in the c-myc proto-oncogene locus: possible involvment in susceptibility or resistance to plasmacytoma induction in BALB/c mice. Mol. Cell. Biol., 11:3095-3104.
  
  
• Beecham EJ, Mushinski JF, Shacter E, Potter M, Bohr VA. 1990. DNA repair in the c-myc locus. In Curr. Topics Microbiol. Immunol. eds. M. Potter and F. Melchers, 166:285-291.
  
  
• Shacter E, Lopes RL, Beecham EJ, Janz S. 1990. DNA damage induced by phorbol ester-stimulated neutrophils is augmented by extracellular cofactors. J. Biol. Chem., 365:6693-6699.
  
  
• Shacter E, Beecham EJ, Covey JM, Kohn KW, Potter M. 1988. Activated neutrophils induce prolonged DNA damage in neighboring cells. Carcinogenesis, 9:2297-2304.
  
  
• Coyne JA, and Beecham EJ. 1987. Habitability within and among natural populations of Drosophila melanogaster. Genetics, 117.